Pesquisa | BVS IEC

1.

Differentiation of exhausted CD8⁺ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.

Tonnerre, Pierre; Wolski, David; Subudhi, Sonu; Aljabban, Jihad; Hoogeveen, Ruben C; Damasio, Marcos; Drescher, Hannah K; Bartsch, Lea M; Tully, Damien C; Sen, Debattama R; Bean, David J; Brown, Joelle; Torres-Cornejo, Almudena; Robidoux, Maxwell; Kvistad, Daniel; Alatrakchi, Nadia; Cui, Ang; Lieb, David; Cheney, James A; Gustafson, Jenna; Lewis-Ximenez, Lia L; Massenet-Regad, Lucile; Eisenhaure, Thomas; Aneja, Jasneet; Haining, W Nicholas; Chung, Raymond T; Hacohen, Nir; Allen, Todd M; Kim, Arthur Y; Lauer, Georg M.

Nat Immunol ; 22(8): 1030-1041, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34312544

2.

Memory-like HCV-specific CD8⁺ T cells retain a molecular scar after cure of chronic HCV infection.

Hensel, Nina; Gu, Zuguang; Wieland, Dominik; Jechow, Katharina; Kemming, Janine; Llewellyn-Lacey, Sian; Gostick, Emma; Sogukpinar, Oezlem; Emmerich, Florian; Price, David A; Bengsch, Bertram; Boettler, Tobias; Neumann-Haefelin, Christoph; Eils, Roland; Conrad, Christian; Bartenschlager, Ralf; Grün, Dominic; Ishaque, Naveed; Thimme, Robert; Hofmann, Maike.

Nat Immunol ; 22(2): 229-239, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33398179

3.

Epigenetic scars of CD8⁺ T cell exhaustion persist after cure of chronic infection in humans.

Yates, Kathleen B; Tonnerre, Pierre; Martin, Genevieve E; Gerdemann, Ulrike; Al Abosy, Rose; Comstock, Dawn E; Weiss, Sarah A; Wolski, David; Tully, Damien C; Chung, Raymond T; Allen, Todd M; Kim, Arthur Y; Fidler, Sarah; Fox, Julie; Frater, John; Lauer, Georg M; Haining, W Nicholas; Sen, Debattama R.

Nat Immunol ; 22(8): 1020-1029, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34312547

4.

Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection.

Frumento, Nicole; Sinnis-Bourozikas, Ariadne; Paul, Harry T; Stavrakis, Georgia; Zahid, Muhammad N; Wang, Shuyi; Ray, Stuart C; Flyak, Andrew I; Shaw, George M; Cox, Andrea L; Bailey, Justin R.

Immunity ; 57(1): 40-51.e5, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38171362

5.

Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance.

Ogega, Clinton O; Skinner, Nicole E; Schoenle, Marta V; Wilcox, Xander E; Frumento, Nicole; Wright, Desiree A; Paul, Harry T; Sinnis-Bourozikas, Ariadne; Clark, Kaitlyn E; Figueroa, Alexis; Bjorkman, Pamela J; Ray, Stuart C; Flyak, Andrew I; Bailey, Justin R.

Immunity ; 57(4): 890-903.e6, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38518779

6.

Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.

Weber, Timm; Potthoff, Julian; Bizu, Sven; Labuhn, Maurice; Dold, Leona; Schoofs, Till; Horning, Marcel; Ercanoglu, Meryem S; Kreer, Christoph; Gieselmann, Lutz; Vanshylla, Kanika; Langhans, Bettina; Janicki, Hanna; Ströh, Luisa J; Knops, Elena; Nierhoff, Dirk; Spengler, Ulrich; Kaiser, Rolf; Bjorkman, Pamela J; Krey, Thomas; Bankwitz, Dorothea; Pfeifer, Nico; Pietschmann, Thomas; Flyak, Andrew I; Klein, Florian.

Immunity ; 55(2): 341-354.e7, 2022 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-34990590

7.

Pioneering a Global Cure for Chronic Hepatitis C Virus Infection.

Vilarinho, Silvia; Lifton, Richard P.

Cell ; 167(1): 12-15, 2016 Sep 22.

Artigo em Inglês | MEDLINE | ID: mdl-27634325

8.

Bringing the Hepatitis C Virus to Life.

Cell ; 167(1): 39-42, 2016 Sep 22.

Artigo em Inglês | MEDLINE | ID: mdl-27634322

9.

Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins.

Chen, Fang; Tzarum, Netanel; Lin, Xiaohe; Giang, Erick; Velázquez-Moctezuma, Rodrigo; Augestad, Elias H; Nagy, Kenna; He, Linling; Hernandez, Mayda; Fouch, Mallorie E; Grinyó, Ariadna; Chavez, Deborah; Doranz, Benjamin J; Prentoe, Jannick; Stanfield, Robyn L; Lanford, Robert; Bukh, Jens; Wilson, Ian A; Zhu, Jiang; Law, Mansun.

Immunity ; 54(4): 781-796.e4, 2021 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-33675683

10.

Hepatitis C virus RNA functionally sequesters miR-122.

Luna, Joseph M; Scheel, Troels K H; Danino, Tal; Shaw, Katharina S; Mele, Aldo; Fak, John J; Nishiuchi, Eiko; Takacs, Constantin N; Catanese, Maria Teresa; de Jong, Ype P; Jacobson, Ira M; Rice, Charles M; Darnell, Robert B.

Cell ; 160(6): 1099-110, 2015 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-25768906

11.

NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng, Hui; Lenarcic, Erik M; Yamane, Daisuke; Wauthier, Eliane; Mo, Jinyao; Guo, Haitao; McGivern, David R; González-López, Olga; Misumi, Ichiro; Reid, Lola M; Whitmire, Jason K; Ting, Jenny P-Y; Duncan, Joseph A; Moorman, Nathaniel J; Lemon, Stanley M.

Nat Immunol ; 18(12): 1299-1309, 2017 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-28967880

12.

RACK1 controls IRES-mediated translation of viruses.

Majzoub, Karim; Hafirassou, Mohamed Lamine; Meignin, Carine; Goto, Akira; Marzi, Stefano; Fedorova, Antonina; Verdier, Yann; Vinh, Joëlle; Hoffmann, Jules A; Martin, Franck; Baumert, Thomas F; Schuster, Catherine; Imler, Jean-Luc.

Cell ; 159(5): 1086-1095, 2014 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-25416947

13.

Molecular architecture of the 40SâeIF1âeIF3 translation initiation complex.

Erzberger, Jan P; Stengel, Florian; Pellarin, Riccardo; Zhang, Suyang; Schaefer, Tanja; Aylett, Christopher H S; Cimermancic, Peter; Boehringer, Daniel; Sali, Andrej; Aebersold, Ruedi; Ban, Nenad.

Cell ; 158(5): 1123-1135, 2014 08 28.

Artigo em Inglês | MEDLINE | ID: mdl-25171412

14.

Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide.

Sherwood, Anna V; Rivera-Rangel, Lizandro R; Ryberg, Line A; Larsen, Helena S; Anker, Klara M; Costa, Rui; Vågbø, Cathrine B; Jakljevic, Eva; Pham, Long V; Fernandez-Antunez, Carlota; Indrisiunaite, Gabriele; Podolska-Charlery, Agnieszka; Grothen, Julius E R; Langvad, Nicklas W; Fossat, Nicolas; Offersgaard, Anna; Al-Chaer, Amal; Nielsen, Louise; Kusnierczyk, Anna; Sølund, Christina; Weis, Nina; Gottwein, Judith M; Holmbeck, Kenn; Bottaro, Sandro; Ramirez, Santseharay; Bukh, Jens; Scheel, Troels K H; Vinther, Jeppe.

Nature ; 619(7971): 811-818, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37407817

15.

T cell exhaustion-a memory locked behind scars.

Yousif, Amir; Ghoneim, Hazem E.

Nat Immunol ; 22(8): 938-940, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34312546

16.

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

He, Guobin; Dhar, Debanjan; Nakagawa, Hayato; Font-Burgada, Joan; Ogata, Hisanobu; Jiang, Yuhong; Shalapour, Shabnam; Seki, Ekihiro; Yost, Shawn E; Jepsen, Kristen; Frazer, Kelly A; Harismendy, Olivier; Hatziapostolou, Maria; Iliopoulos, Dimitrios; Suetsugu, Atsushi; Hoffman, Robert M; Tateishi, Ryosuke; Koike, Kazuhiko; Karin, Michael.

Cell ; 155(2): 384-96, 2013 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-24120137

17.

Altered m⁶A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.

Gokhale, Nandan S; McIntyre, Alexa B R; Mattocks, Melissa D; Holley, Christopher L; Lazear, Helen M; Mason, Christopher E; Horner, Stacy M.

Mol Cell ; 77(3): 542-555.e8, 2020 02 06.

Artigo em Inglês | MEDLINE | ID: mdl-31810760

18.

Guarding the frontiers: the biology of type III interferons.

Wack, Andreas; Terczynska-Dyla, Ewa; Hartmann, Rune.

Nat Immunol ; 16(8): 802-9, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26194286

19.

Structural insights into hepatitis C virus receptor binding and entry.

Kumar, Ashish; Hossain, Reafa A; Yost, Samantha A; Bu, Wei; Wang, Yuanyuan; Dearborn, Altaira D; Grakoui, Arash; Cohen, Jeffrey I; Marcotrigiano, Joseph.

Nature ; 598(7881): 521-525, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34526719

20.

HCV IRES Captures an Actively Translating 80S Ribosome.

Yokoyama, Takeshi; Machida, Kodai; Iwasaki, Wakana; Shigeta, Tomoaki; Nishimoto, Madoka; Takahashi, Mari; Sakamoto, Ayako; Yonemochi, Mayumi; Harada, Yoshie; Shigematsu, Hideki; Shirouzu, Mikako; Tadakuma, Hisashi; Imataka, Hiroaki; Ito, Takuhiro.

Mol Cell ; 74(6): 1205-1214.e8, 2019 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-31080011

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Instituto Evandro Chagas

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